Endocrionology
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Department of Endocrinology of Madurai Medical college and Government Rajaji Hospital was started way back in 1982 by Prof. Dr. K. Kannan MD., DM (Endo). After completing his DM Endocrinology super specialty medical degree at Institute of National importance Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, he started the Endocrinology department at Madurai. Radio Immunoassay (RIA) is the first assay used to estimate thyroid levels was started first in Tamilnadu by Prof. Dr. K. Kannan with the approval from Baba Atomic Research Centre (BARC) Mumbai as per the mandatory regulations. That was the beginning of all the hormonal estimation before the availability of laboratory setup elsewhere.
After the super annuation of Prof. K. Kannan, Prof. Dr. K. Kamaraj MD (2003-2008), subsequently Prof. Dr. J.Sangumani MD, (2008-2018) was the Professor and Head of Department of Endocrinology. During this period faculties worked were Prof Arthur J Asirvatham MD,D.Diab, Dr Jerald Majella MD, Dr Anguvijayam MD, Dr Somasundaram MD, Dr Girithar Babu MD.
Currently Prof. Dr. S. Sridhar MD., DM (Endo), is the Professor and Head of the Department of Endocrinology. After completing his DM Endocrinology in 2012 at PGIMER, Chandigarh, he joined as Assistant Professor here. Subsequently Associate Professor and later promoted as Professor and Head since 2019 onwards. During this period, DM Endocrinology Superspecialty degree course was started first in Tamilnadu Government Medical Colleges, in the year 2019, with annual intake of two seats by erstwhile MCI and approved by NMC currently selected through NEET SS. Till now 5 batches have joined and three batches completed DM Endocrinology course at Madurai Medical College. The present other faculties of Department of Endocrinology are Prof.Dr.E.Subbiah MD, D.Diab, Associate Professor, Dr K.S.Raghavan MD, D.Diab and Dr S.Palanivel MD,DM Assistant professor.
The list of DM Endocrinology post graduates joined DM at Madurai Medical College are
|
Batch |
Year of Joining |
Student Name |
|
I Batch |
2019 |
Dr. Roshan Naziruddin Dr. Komal Sanjay Jog |
|
II Batch |
2020 |
Dr. Rameez Raja Dr. Priyanka |
|
III Batch |
2021 |
Dr. Palanivel Dr. Sinju Sankar |
|
Final year |
2022 |
Dr. Sreekumar Dr. Sreenivasan |
|
II Year |
2023 |
Dr. Dhivya Dr. Aravind Kumar |
SPECIALTY CLINIC run by department of Endocrinology as per the following schedule.
|
Name of the Clinic |
Days on which held |
|
Thyroid Clinic |
All Days |
|
Diabetes Clinic |
All Days |
|
Growth disorder and Obesity Clinic |
Monday |
|
Diabetes in Pregnancy clinic |
Tuesday & Friday |
|
Adrenal and Pituitary disorder Clinic |
Wednesday |
|
Transgender clinic |
Thursday |
|
DSD clinic |
Friday |
|
Young Diabetes Clinic and Diabetic Foot Clinic |
Saturday |
AIMS AND OBJECTIVES:
The aim and objectives for the DM (Endocrinology) course should comprehensively cover all aspects of Endocrinology and Metabolism during a period of three years of study. The student will acquire an exposure in training in the clinical, laboratory, research, outreach and epidemiological perspectives of endocrine disorders, and will acquire adequate skills to treat patients with these disorders on acquiring the degree of DM in Endocrinology.
THEORY SYLLABUS:
All aspects of endocrinology and metabolism will be covered in detail in terms of basic science, clinical knowledge and laboratory-based concepts. Theoretical aspects of medical research and ethics in clinical practice will also be incorporated.
A three years training period designed to meet the minimum requirements for training in Endocrinology prior to certification.
Course and Curriculum of DM Endocrinology & Metabolism:
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Basic Sciences as related to Clinical Endocrinology:
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Hormone receptors / receptor biology
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Genetics in Endocrinology
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Molecular biology
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Hormonal assays
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Disorder of growth and sexual differentiation
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Endocrine disorders in childhood and adolescence
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Diabetes Mellitus
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Hypothalamo – pituitary disorders
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Thyroid disorders
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Reproductive disorders and problems of menopause
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Bone and mineral metabolism
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Adreno-cortical and adreno-medullary disorders
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Metabolic disorders (lipids, carbohydrates and protein metabolism related disorders, including inborn errors of metabolism).
CLINICAL TRAINING:
The ethos of clinical training will focus on developing a candidate who has the ability to:-
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Handle any patient with an endocrine or metabolic disorder as an individual.
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Ability to function and develop multidisciplinary teams to function with:
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Endocrine surgeons and nuclear medicine specialists in handling related clinical problems.
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Work with the vascular surgeons, PMR physicians, orthotists and physiotherapists in driving the aspects of diabetes related foot care and a foot related clinic.
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Developing a laboratory facility which can handle the hormonal and molecular aspects of endocrinology.
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Personality development of the candidate to practice compassionate care in the assessment of their patients coupled with technology.
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Leadership development.
All the candidates should be involved full-time in the direct care of the patients admitted to the endocrine services as resident staff. This will include taking a complete history, performing a comprehensive examination, ordering appropriate investigations and interpreting results. Additionally, residents will be required to attend outpatient endocrine clinics where consultants will be available for on spot consultations. The residents will be expected to maintain a log book of seminars and journal clubs presented by them, and interesting cases (at least 20) which they have worked up in detail, and procedures performed during their tenure of 3 years.
Clinical / Laboratory Research:
Residents should be provided a 3-month exposure to hormone assays and clinical biochemistry lab in the Department of Endocrinology to provide insight and hands on training in hormone assays and other laboratory techniques.
Training Programme:
I Postings:
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Inpatient ward: 24 months
II Speciality Clinics:
Students are encouraged to attend special clinics viz.,
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Foot clinic once a week
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Adult Young diabetes clinic once a week
-
Transgender clinic once a week
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Pituitary and adrenal clinic once a week
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Metabolic bone clinic once a week
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Thyroid clinic once a week
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Obesity and DSD clinic once a week
II. Multi-departmental meetings:
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Radio diagnosis – Endocrinology
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Pathology- Endocrinology
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Neurosurgery- Endocrinology
During II year, students are encouraged to undergo special postings for learning new advanced techniques / Procedure / Skills in institutions of higher repute where the requisite facilities are available without affecting the duties of the parent department.
SKILL TRAINING REQUIREMENTS:
Foundational clinical skills based on internal medicine concepts, and developed further to focus on the historical assessment and clinical examination of the endocrine system
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In depth theoretical knowledge of the functioning of the endocrine glands and the physiology of the endocrine systems.
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Ability to understand hormonal assays and setting them up in a laboratory setting.
Training in allied specialities:
Endocrine Radiology:
At least fortnightly meetings with Department of Radiology. These meetings will be conducted to discuss imaging, conventional and CT, MRI, or patients seen in the OPD and in-patient service.
Nuclear Medicine:
The residents will be given training in the principles of scanning of various endocrine organs and interpretation of isotope scans. Additionally, regular weekly conferences should be scheduled with the nuclear medicine department where faculty and the resident staff should discuss interesting scans of the previous week.
Training in Pathology:
It is primarily aimed at providing trainee insight into the area of endocrine-pathology such that the trainee will keep himself updated on emerging methods and trends in endocrine pathology.
Molecular biology courses:
It would be appropriate to provide the resident a one week exposure to molecular techniques as relevant to endocrinology. Procedures such as DNA extraction, PCR, RFLP, Southern blots and chromatography should be explained to the candidates.
TEACHING METHODOLOGY:
Ward / OPD patient management. Peri operative Management
Assisting / performing operative procedures. Long and short topic presentations.
Ward rounds, case presentations and discussions. Combined ward rounds with Medical Gastroenterologist.
Clinico-radiological and clinico-pathological conferences.
Inter-departmental Periodical meeting on relevant topics with Department of Anatomy, Physiology, Bio-chemistry and Microbiology.
Journal club. Research review.
Problem solving sessions.
Weekly Tumour Board discussions with Radiation and Medical Oncologist. Guest and in-house lectures. Conferences, seminars and CME’s.
Participation in workshops, etc.
Teaching undergraduates / postgraduates / paramedical staff. Weekly Surgical audit (patient care review meeting).
Biomedical equipments use and maintenance.
RESEARCH WORK:
The candidate will be trained in the ability to
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Frame a research question.
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Plan a study to answer the question.
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Collect the relevant information and
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Evaluate appropriately the collected data to draw a conclusion.
The candidate should become conversant with the reporting of these results as a research paper, in journals and as a presentation in conferences.
The activities would consist of:
Planning and organizing relevant animal / clinical studies to be submitted as a dissertation at the end of the course.
Students should compulsorily attend Research Methodology workshop conducted by the University within first six months of D.M. Course.
Dr.S.SRIDHAR MBBS, MD, DM (Endocrinology)
Dr.S.SRIDHAR
Professor & Head
Qualification : MBBS, MD, DM (Endocrinology)
TNMC Registration No: 74428
Dr.E.SUBBIAH
Associate Professor
Qualification : MBBS, MD, D. DIAB
TNMC Registration No: 54113
Dr.K.S.RAGHAVAN
Assistant Professor
Qualification : MBBS, MD, D. DIAB
TNMC Registration No: 64014
Dr.S.PALANIVEL
Associate Professor
Qualification : MBBS, MD.DM (Endocrinology)
TNMC Registration No: 83369
ENDOCRINOLOGY LAB SERVICES
The backbone of department is hormonal assay laboratory since its inception in 1982. From the Radio Immunoassay (RIA) in 1980-2000, thyroid function test was assessed by Enzyme linked Immuno-Sorbent Assay (ELISA) in 2001-2015. In 2015, we have updated our assay methodology into Chemiluminescent Immuno Assay (CLIA), by Maglumi 800 equipment, was the major breakthrough, in development of Endocrinology lab and it is attached to Endocrinology outpatient clinic itself. From 2015 to 2019, through the Maglumi CLIA equipment, T3, T4, TSH, LH, FSH, Prolactin and Total Testosterone hormonal tests were performed.
In 2019, state of art Roche-Cobas e411 (made in Germany), the equipment cost of Rs. 25 lakhs, was purchased with the help of DRDO department of Madurai Collector through Self Sufficiency Scheme (SSS scheme). Through this equipment currently we do most of hormonal analysis in Endocrinology from all the specialty tests. All the above hormonal tests are performed free of cost for patients referred from all the Departments of Government Rajaji Hospital including General Medicine, General Surgery, Obstetrics and Gynaecology, Neonatology, Paediatrics, and Neurosurgery etc.
The hormonal parameters currently performed through Roche Cobas e411 (ECLIA Analyzer) are
|
T3 |
TSH Receptor Antibody (TRAB) |
LH |
Growth Hormone |
|
T4 |
Serum Thyroglobulin |
FSH |
IGF-1 |
|
TSH |
Anti-Thyroglobulin Antibody |
Prolactin |
Insulin |
|
Free T4 |
AMH |
Total Testosterone |
C-peptide |
|
Anti-TPO |
|
Estradiol |
SHBG |
In 2023, Department of Endocrinology purchased WHO standard Bio Rad D-10, HPLC equipment (gold standard) purchased through TNMSC by CMCHIS fund, which is capable of doing HBA1C (Glycosylated Hemoglobin) for diagnosis and monitoring of glycemic control in Diabetes mellitus. In 2024, Department purchased ELISA washer and reader to do rare tests like Leptin and glucagon through CMCHIS fund.
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Government Rajaji Hospital, Madurai - 2024 Department of Endocrinology |
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2024 |
OP & IP CASES - 2024 |
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MONTH |
MALE |
FEMALE |
CHILD |
Monthly OP Census |
Monthly |
|
January |
1041 |
5209 |
462 |
6712 |
96 |
|
February |
1155 |
5158 |
606 |
6919 |
74 |
|
March |
1266 |
4576 |
698 |
6540 |
76 |
|
April |
953 |
4280 |
592 |
5825 |
97 |
|
May |
1071 |
4754 |
585 |
6410 |
103 |
|
June |
975 |
4199 |
557 |
5731 |
73 |
|
July |
1173 |
4783 |
609 |
6565 |
86 |
|
August |
1049 |
4444 |
617 |
6110 |
92 |
|
September |
954 |
4172 |
580 |
5706 |
77 |
|
October |
980 |
3874 |
560 |
5414 |
92 |
|
November |
1044 |
4109 |
552 |
5705 |
93 |
|
December |
894 |
4258 |
601 |
5753 |
81 |
|
TOTAL |
12555 |
53816 |
7019 |
73390 |
1040 |
Ongoing Research Projects from Department of Endocrinology
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By faculties |
Research Project Name |
|
2 |
Dr.S.SRIDHAR |
Clinical, Hormonal and Y chromosome Micro deletion Profile of infertile male with non-obstructive azoospermia |
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By Post Graduates |
Research Project Name
|
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1 |
Dr.PL.Sreenivasan |
Randomized comparative study on Tamoxifen and Letrozole in treatment of Pubertal Gynecomastia |
|
2 |
Dr.P.S.Sreekumar |
Single point insulin sensitivity estimator as a predictor of insulin resistance in metabolic syndrome- a study in south Indian population |
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3 |
Dr.S.Dhivya |
Molecular genetic analysis of severe short stature children and adolescents and predictors of response to growth hormone therapy |
|
4 |
Dr.Aravind Kumar |
Clinical, Biochemical, genetic profile, and gender identity pattern in disorders of sex development |
Publications List from Department of Endocrinology – Research Articles
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S No |
Title of the Article and Citations |
Name of the Journal |
Date of Publication |
PubMed ID |
|
1 |
A Randomized Controlled Trial Comparing Testosterone Enanthate and Testosterone Undecanoate as a Gender Affirming Hormonal Therapy in Trans Males. Clin Endocrinol (Oxf). 2025 Feb 26. doi: 10.1111/cen.15223. |
Clinical Endocrinology
|
Feb 2025 |
PMID: 40012162 |
|
2 |
Determinants of childhood and adolescent obesity and its effect on metabolism in South Indian population. J Pediatr Endocrinol Metab. 2025 Mar 20. |
Journal of Pediatric Endocrinology and Metabolism |
March 2025 |
PMID: 40106712 |
|
3 |
Clinical Presentation and Co-Morbidities in Bardet-Biedel Syndrome: Case Series from a Single Centre. Indian J Endocrinol Metab. 2025 Jan-Feb;29(1):89-94. doi: 10.4103/ijem.ijem_278_24.
|
Indian Journal of Endocrinology and Metabolism |
January 2025 |
PMID: 4018185 |
|
4 |
The Role of Neck Ultrasonography and Nuclear Imaging in the Diagnosis of Congenital Hypothyroidism. .Indian J Endocrinol Metab. 2024 Nov-Dec;28(6):611-616. doi: 10.4103/ijem.ijem_7_24. |
Indian Journal of Endocrinology and Metabolism |
November 2024 |
PMID: 39881764 |
|
5 |
Endocrine |
May 2024 |
PMID: 37861945.
|
|
|
6 |
The Impact of Body Mass Index, Residual Beta Cell Function and Estimated Glucose Disposal Rate on the Development of Double Diabetes and Microvascular Complications in Patients with Type 1 Diabetes Mellitus. Cureus. 2023 Nov 17;15(11): e48979. |
Cureus |
November 2023 |
PMID: 38111445
|
|
7 |
Epidemiology, Clinical Profile, and Analysis of Risk Factors in COVID Associated Rhino-orbito-cerebral Mucormycosis Patients - An Observational Study. Indian J Endocrinol Metab. 2023 Nov-Dec; 27(6):519-523. |
Indian Journal of Endocrinology and Metabolism |
November 2023 |
PMID: 38371190
|
|
8 |
Pituitary |
September 2023 |
PMID: 37695468 |
|
|
9 |
Clinical Endocrinology
|
August 2023 |
PMID: 37265016. |
|
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10 |
Comparison of Novel Biomarkers of Insulin Resistance with Homeostasis Model Assessment of Insulin Resistance, Its Correlation to Metabolic Syndrome in South Indian Population and Proposition of Population Specific Cutoffs for These Indices. Cureus 15(1): e33653. DOI 10.7759/cureus.33653 |
Cureus |
November 2023 |
PMID: 36788883
|
|
10 |
|
Indian Journal of Endocrinology and Metabolism |
July 2022 |
PMID: 36185961 |
|
11 |
The spectrum of CYP21A2 gene mutations from 16 families of congenital adrenal hyperplasia: Genotype‑phenotype correlation. Indian J Endocr Metab 2021;25:532-7. Indian J Endocrinol Metab. 2021 Nov-Dec;25(6):532-537. doi: 10.4103/ijem.ijem_442_21. Epub 2022 Feb 17. |
Indian Journal of Endocrinology and Metabolism |
November 2021 |
PMID: 35355919 |
|
12 |
Clinical Profile of Addison’s disease in a tertiary care Institute, Southern India – The Changing Landscape. Indian J Endocr Metab 2022;26 (1): 50-54.
|
Indian Journal of Endocrinology and Metabolism |
January 2022 |
PMID: 35662761 |
Case Reports Publications from Department of Endocrinology
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S No |
Title of the Article and Citations |
Name of the Journal |
Date of Publication |
Index Details |
|
1 |
A curative etiology of severe hirsutism with virilization – Sertoli-Leydig cell ovarian tumor
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Indian Journal of Endocrinology and Metabolism |
November 2024 |
Google Scholar |
|
2 |
Refractory headache, deafness, and multiple lytic lesions- Paget's disease
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QJM: An International Journal of Medicine |Oxford Academic
|
May 2024 |
Pubmed PMID 38696771
|
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3 |
Familial Hypercholesterolemia and Multiple Xanthomatosis |
Journal of the Association of Physicians of India |
October 2023 |
|
|
4 |
Thionamide-responsive alopecia areata in an 11-year-old girl.
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Indian Journal of Endocrinology and Metabolism |
August 2023 |
Pubmed PMID 37867988 |
|
5 |
Highly Active Antiretroviral Therapy-associated Lipodystrophy: Pseudo-Cushing's Syndrome |
Journal of the Association of Physicians of India |
February 2023 |
Pubmed PMID 37354477
|
|
6 |
A case of Childhood-onset hypertension with twin tumours |
Indian Journal of Endocrinology and Metabolism |
September 2022 |
Google Scholar |
|
7 |
Fahr's Disease and Hypoparathyroidism - A Missing Link
|
Neurology India |
July 2022 |
Pubmed PMID 35864655
|
|
8 |
Congruency the ART of Being Real" - 46XY DSD Due to 5α Reductase Deficiency - Challenges in Decision Making |
Indian Journal of Endocrinology and Metabolism |
January 2022 |
Pubmed PMID 35300438
|
|
9 |
Secondary Amenorrhea in a case of Gonadotropin Independent Precocious Puberty: McCune-Albright Syndrome. |
International Journal of Reproduction, Contraception, Obstetrics and Gynecology |
September 2021 |
Google Scholar |
|
10 |
A Rare Association of Obesity, Diabetes Mellitus, and Bilateral Cryptorchidism: Prader-Willi Syndrome
|
Journal of the Association of Physicians of India |
November 2016 |
Pubmed PMID 27805351
|
|
11 |
Stones, sugar and air-emphysematous pyelonephritis
|
QJM: An International Journal of Medicine Oxford Academic
|
June 2014 |
Pubmed PMID 24929093
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1) Prof. Dr.Kannan 1982 – 2001
2) Prof.Dr.M.Kamaraj 2001-2008
3) Prof.Dr.J.Sangumani 2008-2019
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